OXA 06 dihydrochloride

Cat. No. 5182

OXA 06 dihydrochloride C21H18FN3.2HCl

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Chemical Name: 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride

Biological Activity

Potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.

Technical Data

M.Wt:
404.31
Formula:
C21H18FN3.2HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Vigil et al (2012) ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 72 5338. PMID: 22942252.

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Keywords: OXA 06 dihydrochloride, supplier, OXA06, dihydrochloride, rho, kinases, ROCK, potent, inhibitors, inhibits, 944955_32_2, Tocris Bioscience, Rho-Kinases Inhibitor products

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