Ferrostatin 1

Cat. No. 5180

Ferrostatin 1 C15H22N2O2 [347174-05-4]

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Chemical Name: Ethyl 3-amino-4-(cyclohexylamino)benzoate

Biological Activity

Selective inhibitor of erastin induced ferroptosis (EC50 = 60 nM). Specifically inhibits Ras selective lethal compound -induced death, but not cell death induced by other oxidative lethal compounds and apoptosis-inducing agents. Inhibits ferroptosis in cancer cells; also inhibits glutamate-induced cell death in organotypic rat brain slices. Prevents erastin induced accumulation of cytosolic and lipid reactive oxygen species.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Skouta et al (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J.Am.Chem.Soc. 136 4551. PMID: 24592866.

Louandre et al (2013) Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib. Int.J.Cancer 133 1732. PMID: 23505071.

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060. PMID: 22632970.

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Keywords: Ferrostatin 1, supplier, Selective, inhibitors, inhibits, erastin, induced, ferroptosis, RAS, selective, lethal, compound, RSL, ROS, Tocris Bioscience, Other Apoptosis products

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