(S)-(-)-Bay K 8644

Cat. No. 1546

(S)-(-)-Bay K 8644 C16H15F3N2O4 [98625-26-4]

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Chemical Name: (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester

Biological Activity

L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. Enantiomer of (±)-Bay K 8644 (Cat. No. 1544).

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ravens and Schopper (1990) Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch.Pharmacol. 341 232. PMID: 1692975.

O'Neill and Bolger (1988) Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644. Brain Res.Bull. 21 865. PMID: 2465070.

Franckowiak et al (1985) The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels. Eur.J.Pharmacol. 114 223. PMID: 2412855.

If you know of a relevant reference for (S)-(-)-Bay K 8644 please let us know.

Citations are publications that use Tocris products. Selected citations for (S)-(-)-Bay K 8644 include:

Burtscher et al (2014) Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2. Biochim Biophys Acta 1838 2053. PMID: 24796500.

Landstrom et al (2011) Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Eneuro 4 214. PMID: 21216834.

Do you know of a great paper that uses (S)-(-)-Bay K 8644 from Tocris? If so please let us know.

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