Cat. No. 5179
Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2
Biological ActivitySelective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863. PMID: 23484054.
Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054.
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Keywords: TCID, supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products
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