TCID

Cat. No. 5179

TCID C9H2Cl4O2 [30675-13-9]

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Chemical Name: 4,5,6,7-Tetrachloro-1H-Indene-1,3(2H)-dione

Biological Activity

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor (IC50 = 0.6 μM). Exhibits >100-fold selectivity for UCH-L3 over UCH-L1. Diminishes glycine transporter GlyT2 ubiquitination in brain stem and spinal cord primary neurons.

Technical Data

M.Wt:
283.92
Formula:
C9H2Cl4O2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
30675-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

de Juan-Sanz et al (2013) Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster. PLoS ONE 8 e58863. PMID: 23484054.

Liu et al (2003) Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem.Biol. 10 837. PMID: 14522054.

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Keywords: TCID, supplier, selective, ubiquitin, c-terminal, hydrolase-L3, UCH-L3, UCHL3, inhibitors, inhibits, deubiquitinating, enzymes, DUBs, ubiquitination, Tocris Bioscience, Deubiquitinating Enzyme Inhibitor products

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