AEBSF

Cat. No. 5175

AEBSF C8H10FNO2S.HCl [30827-99-7]

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Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

Biological Activity

Broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.

Technical Data

M.Wt:
239.69
Formula:
C8H10FNO2S.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
30827-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Saw et al (2012) Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS ONE 7 e41107. PMID: 22829914.

Diatchuk et al (1997) Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J.Biol.Chem. 272 13292. PMID: 9148950.

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Citations are publications that use Tocris products.

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Keywords: AEBSF, supplier, broad, spectrum, irreversible, serine, proteases, inhibitors, inhibits, trypsin, chymotrypsin, plasmin, thrombin, kallikreins, Tocris Bioscience, Other Protease Inhibitor products

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