Cat. No. 5172
Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimeth
Biological ActivityInhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731. PMID: 24077179 .
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Keywords: FLI 06, supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products
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