FLI 06

Cat. No. 5172

FLI 06 C25H30N2O5 [313967-18-9]

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Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate

Biological Activity

Inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731. PMID: 24077179 .

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Keywords: FLI 06, supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Tocris Bioscience, Translocation, Exocytosis & Endocytosis products

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