NBOH-2C-CN hydrochloride

Cat. No. 5171

NBOH-2C-CN hydrochloride C18H20N2O3.HCl [1539266-32-4]

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Alternative Name: 25CN-NBOH

Chemical Name: 4-[2-[[(2-Hydroxyphenyl)methyl]amino]ethyl]-2,5-dimethoxybenzonitrile hydrochloride

Biological Activity

High affinity, selective 5-HT2A agonist (Ki = 1.3 nM). Exhibits 100-fold selectivity for 5-HT2A over 5-HT2C. Elicits head twitch behavior in mice.

Technical Data

M.Wt:
348.82
Formula:
C18H20N2O3.HCl
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
1539266-32-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Fantegrossi et al (2014) Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice. Psychopharmacology (Berl.) 232 1039. PMID: 25224567.

Hansen et al (2014) Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS.Chem.Neurosci. 5 243. PMID: 24397362.

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Keywords: NBOH-2C-CN hydrochloride, supplier, serotonin, potent, selective, high, affinity, 5-ht, 5-ht2a, agonists, receptors, hallucinogen-like, Tocris Bioscience, 5-HT2A Receptor Agonist products

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