Cat. No. 5168
Chemical Name: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2
Biological ActivityPotent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 38 1060. PMID: 23303071.
Pietrancosta et al (2010) Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 18 6922. PMID: 20708942.
Ogita et al (2001) Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 77 34. PMID: 11279259.
Feenstra et al (1992) What is actually stained by rose bengal? Arch.Ophthalmol. 110 984. PMID: 1637285.
If you know of a relevant reference for Rose Bengal please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Rose Bengal from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Rose Bengal, supplier, potent, non, competitive, inhibitors, inhibits, membrane, permeable, glutamate, vesicular, glutamate, transporters, VGLUT, excitatory, amino, acid, neuroprotective, Rose, Bengal, Tocris Bioscience, Vesicular Monoamine Transporter Inhibitor products