Congo Red

Cat. No. 5167

Congo Red C32H22N6Na2O6S2 [573-58-0]

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Chemical Name: 3,3'-[(1,1'-Biphenyl)-4,4'-diyl-bis(2,1-diazenediyl)]bis(4-amino-1-naphthalenesulfonic acid) disodium salt

Biological Activity

VGlut inhibitor; decreases synaptic transmission in the dentate gyrus. Also an amyloid fibril-binding dye; inhibits Fib-beta A neurotoxicity by inhibiting fibril formation or by binding to preformed fibrils. Also inhibits the pancreatic islet cell toxicity of diabetes-associated amylin. Excitation wavelength is 497 nm.

Technical Data

M.Wt:
696.66
Formula:
C32H22N6Na2O6S2
Solubility:
Soluble to 10 mM in water and to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
573-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. 38 1060. PMID: 23303071 .

Neale et al (2013) Effect of VGLUT inhibitors on glutamatergic synaptic transmission in the rodent hippocampus and prefrontal cortex. Neurochem.Int. 73 159. PMID: 24121008.

Lorenzo et al (1994) Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc.Natl.Acad.Sci.USA 91 12243. PMID: 7991613.

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Keywords: Congo Red, supplier, vesicular, glutamate, transporters, VGLUT, dye, amyloid, fibril, binding, inhibitors, inhibits, Alzheimer's, disease, diabetes, direct, red, neuroprotective, Tocris Bioscience, Labels & Stain products

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