Cat. No. 5164
Chemical Name: 3-[[[3-[4-[(Methylsulfonyl)amino]ph
Biological ActivityPotent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). Exhibits anxiolytic effects in rat models.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Yao et al (2010) Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use-dependent inhibitor of dopamine synthesis. Nat.Med. 16 1024. PMID: 20729865.
Overstreet et al (2009) A selective ALDH-2 inhibitor reduces anxiety in rats. Pharmacol.Biochem.Behav. 94 255. PMID: 19747934.
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Keywords: CVT 10216, supplier, CVT10216, potent, selective, reversible, inhibitors, inhibits, aldehyde, dehydrogenase, 2, ALDH2, anxiolytics, anti-anxiety, Tocris Bioscience, Aldehyde Dehydrogenase Inhibitor products
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