Splitomicin

Cat. No. 1542

Splitomicin C13H10O2 [5690-03-9]

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Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

M.Wt:
198.22
Formula:
C13H10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
5690-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bedalov et al (2001) Identification of a small molecule inhibitor of Sir2p. Proc.Natl.Acad.Sci.U.S.A. 98 15113. PMID: 11752457.

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Citations are publications that use Tocris products. Selected citations for Splitomicin include:

Kumari and Usdin (2014) Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription. Hum Mol Genet 23 6575. PMID: 25055869.

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Keywords: Splitomicin, supplier, Sir2p, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Tocris Bioscience, Sir 2-like Family Deacetylase Inhibitor products

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