DCPIB

Cat. No. 1540

DCPIB C22H28Cl2O4 [82749-70-0]

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Chemical Name: 4-[(2-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid

Biological Activity

Potent, selective blocker of the volume-sensitive anion channel (VSAC) in rat pancreatic β-cells (IC50 ~ 2 μM) and ICl,swell in various cardiovascular tissues (IC50 = 4.1 μM in CPAE cells); blockade is voltage-independent. Displays minimal inhibition of other Cl- and K+ currents (< 10% inhibition at 10 μM). Inhibits glucose-stimulated insulin secretion in intact β-cells via VSAC inhibition and indirect KATP channel activation. Reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro.

Technical Data

M.Wt:
427.37
Formula:
C22H28Cl2O4
Solubility:
Soluble to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
82749-70-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Best et al (2004) Inhibition of glucose-induced electrical activity in rat pancreatic β-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents. Eur.J.Pharmacol. 489 13. PMID: 15063150.

Decher et al (2001) DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br.J.Pharmacol. 134 1467. PMID: 11724753.

Bourke et al (1981) Adenosine-stimulated astroglial swelling in cat cerebral cortex in vivo with total inhibition by a non-diuretic acylaryloxyacid derivative. J.Neurosurg. 55 364. PMID: 6267227.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for DCPIB include:

Catalán et al (2015) A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland. Int J Clin Exp Med 112 2263. PMID: 25646474.

Draganov et al (2015) Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. J Cell Sci 5 16222. PMID: 26552848.

Takada et al (2014) Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes. Dig Dis Sci 127 4159. PMID: 25097230.

Hawkins et al (2013) Electrophysiological characteristics of enteric neurons isolated from the immortomouse. Proc Natl Acad Sci U S A 58 1516. PMID: 23371009.

Sabirov et al (2013) Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. PLoS One 8 e55646. PMID: 23383255.

Hyzinski-García et al (2011) Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures. J Neurochem 118 140. PMID: 21517854.

Li and Olson (2008) Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons. Am J Physiol Cell Physiol 295 C1550. PMID: 18923056.

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Keywords: DCPIB, supplier, Selective, blockers, VSAC, IClswell, volume-sensitive, anion, channels, chloride, Tocris Bioscience, Chloride Channel Blocker products

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