HNGF6A

Cat. No. 5154

HNGF6A Met-Ala-Pro-Arg-Gly-Ala-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

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Biological Activity

Humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. Also enhances glucose sensing in βTC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo.

Technical Data

M.Wt:
2581.13
Formula:
C112H198N34O31S2
Sequence:
MAPRGASCLLLLTGEIDLPVKRRA
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1093111-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kuliawat et al (2013) Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J. 27 4890. PMID: 23995290 .

Oh et al (2011) Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 219 65. PMID: 21763658.

Muzumdar et al (2009) Humanin: a novel central regulator of peripheral insulin action. PLoS One. 4 e6334. PMID: 19623253 .

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: HNGF6A, supplier, Alzheimer's, disease, insulin, diabetes, β, cells, humanin, endothelial, dysfunction, atherosclerosis, humanin, analogue, HN, beta, analog, Tocris Bioscience, Insulin and Insulin-like Receptor products

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