Cat. No. 5153
Chemical Name: 2-(2-Amino-1H-benzimidazole-1-yl)-8
Biological ActivityATP-competitive inhibitor of p97 ATPase (IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297. PMID: 23316025.
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Keywords: ML 240, supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibitors, inhibits, Tocris Bioscience, Other ATPase Inhibitor products