Lamotrigine

Cat. No. 1611

Lamotrigine C9H7Cl2N5 [84057-84-1]

Price and Availability

For Lamotrigine pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine

Biological Activity

Anticonvulsant. Inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Also blocks heterologously expressed and native α4β2 nAChRs with a similar affinity to Na+ channels. Water-soluble salt available (lamotrigine isethionate, Cat. No. 2289).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
256.09
Formula:
C9H7Cl2N5
Solubility:
Soluble to 10 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
84057-84-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zheng et al (2010) The anticonvulsive drug lamotrigine blocks neuronal α4β2 nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 335 401. PMID: 20688974.

Grunze et al (1998) Modulation of calcium and potassium currents by lamotrigine. Neuropsychobiology 38 131. PMID: 9778600.

Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522. PMID: 9184596.

Leach et al (1991) Neurochemical and behavioral aspects of lamotrigine. Epilepsia 32 S4. PMID: 1685439.

If you know of a relevant reference for Lamotrigine please let us know.

Citations are publications that use Tocris products. Selected citations for Lamotrigine include:

Kashyap et al (2015) Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation. J Neurosci 2. PMID: 26709376.

Do you know of a great paper that uses Lamotrigine from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Lamotrigine, supplier, inhibitors, glutamate, release, Anticonvulsant, Blocks, Na+, K+, Ca2+, calcium, sodium, potassium, channels, inhibits, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Channel, modulators, VDAC, GlaxoSmithKline, GSK, Tocris Bioscience, Miscellaneous Glutamate products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

mGlu Receptors Scientific Review

Written by Francine Acher

Metabotropic Glutamate Receptors Scientific Review

Our Metabotropic Glutamate Receptor review gives an overview of the pharmacological ligands used to study the mGlu receptors . Request copy or view PDF today.

divider line

Parkinson's Life Science Poster

Written by Anthony H.V. Schapira

Parkinson's Life Science Poster

Our Parkinson's disease (PD) poster summarizes the neurobiology of the disease, and highlights current therapeutic treatments for symptomatic PD. Request copy or view PDF today.

divider line

Depression Life Science Poster

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

Learning and Memory Life Science Poster

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

divider line

New Products in this Area

MDNI-caged-L-glutamate

Stable photoreleaser of L-glutamate

TASP 0433864

Selective mGlu2 receptor positive allosteric modulator

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.