ACET

Cat. No. 2728

ACET C20H19N3O6S [936095-50-0]

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Chemical Name: (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-5-phenylthiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione

Biological Activity

Potent and selective GluR5-containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA receptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.

Technical Data

M.Wt:
429.45
Formula:
C20H19N3O6S
Solubility:
Soluble to 10 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
936095-50-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Dargan et al (2009) ACET is a highly potent and specific kainate receptor antagonist: Characterisation and effects on hippocampal mossy fibre function. Neuropharmacology 56 121. PMID: 18789344.

Dolman et al (2007) Synthesis and pharmacological characterisation of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. J.Med.Chem. 50 1558. PMID: 17348638.

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Keywords: ACET, supplier, Potent, antagonists, GluR5-containing, kainate, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Tocris Bioscience, Kainate Receptor Antagonist products

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