SKF 83566 hydrobromide
Cat. No. 1586
Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl
Biological ActivityPotent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Conley et al (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J.Pharmacol.Exp.Ther. 347 276. PMID: 24008337.
Fritts et al (1998) Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride. Pharmacol.Biochem.Behav. 60 639. PMID: 9678647.
Meyer et al (1993) Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol.Biochem.Behav. 44 429. PMID: 8446676.
Ohlstein and Berkowitz (1985) SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors. Eur.J.Pharmacol. 108 205. PMID: 3884345.
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Citations are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:
Cassar et al (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Learn Mem 24 197. PMID: 25158689.
Savalli et al (2015) Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory. J Neurosci 22 69. PMID: 25593292.
Xing et al (2015) Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Hum Mol Genet 9 310. PMID: 26388722.
Belinsky et al (2013) Dopamine receptors in human embryonic stem cell neurodifferentiation. Stem Cells Dev 22 1522. PMID: 23286225.
Billes et al (2012) Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism. Mol Metab 1 86. PMID: 24024122.
Liu et al (2008) Increased dopamine level enhances male-male courtship in Drosophila. World J Gastroenterol 28 5539. PMID: 18495888.
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Keywords: SKF 83566 hydrobromide, supplier, Potent, selective, D1-like, antagonists, Dopamine, Receptors, D5, dopaminergic, SKF83566, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Antagonist products
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