BAY-u 3405

Cat. No. 2732

BAY-u 3405 C21H21FN2O4S [116649-85-5]

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Alternative Name: Ramatroban

Chemical Name: (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid

Biological Activity

Potent dual antagonist of TP/DP2 (CRTH2) prostanoid receptors (Ki values are 4.3, 4.5 and > 10000 nM for hDP2, hTP and hDP1 receptors respectively). Suppresses PGD2-induced migration of human eosinophils (IC50 = 170 nM).

Technical Data

M.Wt:
416.47
Formula:
C21H21FN2O4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
116649-85-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ulven and Kostenis (2005) Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J.Med.Chem. 48 897. PMID: 15715457.

Ishizuka et al (2004) Ramatroban (BAY u3405): a novel dual antagonist of TXA2 receptor and CRTh2, a newly identified prostaglandin D2 receptor. Cardiovasc.Drug Rev. 22 71. PMID: 15179446.

Sundstrom et al (2003) Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung. J.Pharmacol.Exp.Ther. 307 408. PMID: 12954791.

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Keywords: BAY-u 3405, supplier, Dual, TP/DP2, CRTH2, receptors, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, BAY-u3405, Tocris Bioscience, Prostanoid Receptor Antagonist products

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