GR 125487 sulfamate

Cat. No. 1658

GR 125487 sulfamate C19H26FN3O5S.H2NSO3H [859502-43-5]

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Chemical Name: 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate

Biological Activity

Potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
524.58
Formula:
C19H26FN3O5S.H2NSO3H
Solubility:
Soluble to 10 mM in water with gentle warming
Purity:
>97 %
Storage:
Desiccate at RT
CAS No:
859502-43-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Horikoshi et al (2001) Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisplatin in Suncus murinus. Jpn.J.Pharmacol. 85 70. PMID: 11243577.

Galeotti et al (1998) Role of 5-HT4 receptors in the mouse passive avoidance test. J.Pharmacol.Exp.Ther. 286 1115. PMID: 9732367.

Schiavi et al (1994) Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33 543. PMID: 7984293.

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Keywords: GR 125487 sulfamate, supplier, Potent, selective, 5-HT4, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, GR125487, sulfamate, GlaxoSmithKline, GSK, Tocris Bioscience, 5-HT4 Receptor Antagonist products

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