GR 64349

Cat. No. 1668

GR 64349 Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2

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Biological Activity

Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
921.12
Formula:
C42H68N10O11S
Sequence:
KDSFVGLM

(Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 20% ethanol / water
Storage:
Desiccate at -20°C
CAS No:
137593-52-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Chang et al (2000) Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 294 147. PMID: 10871306.

Chizh et al (1995) Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br.J.Pharmacol. 115 1013. PMID: 7582497.

Deal et al (1992) Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J.Med.Chem. 35 4195. PMID: 1331460.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for GR 64349 include:

León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206. PMID: 26755241.

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Sci Rep 156 627. PMID: 25422875.

Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576. PMID: 25490143.

Do you know of a great paper that uses GR 64349 from Tocris? If so please let us know.

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Keywords: GR 64349, supplier, Potent, selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, GR64349, GlaxoSmithKline, GSK, Tocris Bioscience, NK2 Receptor Agonist products

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