Cat. No. 1669
Biological ActivityPotent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
(Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sakurada et al (1999) Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides 20 301. PMID: 10422886.
Meini et al (1995) GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides 28 99. PMID: 7538205.
Hall and Morton (1991) Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 632 404. PMID: 1719888.
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Citations are publications that use Tocris products. Selected citations for GR 73632 include:
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206. PMID: 26755241.
León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206. PMID: 26755241.
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Mol Psychiatry 156 627. PMID: 25422875.
Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576. PMID: 25490143.
Liu et al (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27 3549. PMID: 23722916.
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Keywords: GR 73632, supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, GR73632, GlaxoSmithKline, GSK, Tocris Bioscience, NK1 Receptor Agonist products
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December 13 - 15, 2016