Cat. No. 1663
Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dim
Biological ActivityPotent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.
Licensing InformationSold for research purposes under agreement from GlaxoSmithKline
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Broom et al (2002) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303 723. PMID: 12388657.
Chang et al (1993) A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J.Pharmacol.Exp.Ther. 267 852. PMID: 8246159.
Dykstra et al (1993) A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875. PMID: 8246162.
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Citations are publications that use Tocris products. Selected citations for BW 373U86 include:
Donner et al (2013) Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats. J Allergy Clin Immunol 6 457. PMID: 23161371.
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Keywords: BW 373U86, supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, BW373U86, GlaxoSmithKline, GSK, Tocris Bioscience, δ Opioid Receptor Agonist products
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