BW 373U86

Cat. No. 1663

BW 373U86 C27H37N3O2 [155836-50-3]

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Chemical Name: 4-[(αR*)-α-((2S*,5R*)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide

Biological Activity

Potent, selective non-peptide δ-opioid receptor agonist. Ki values are 1.8, 15 and 34 nM for δ, μ and κ receptors respectively. Centrally active following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M.Wt:
435.61
Formula:
C27H37N3O2
Solubility:
Soluble to 100 mM in 1eq. HCl
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
155836-50-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Broom et al (2002) Comparison of receptor mechanisms and efficacy requirements for δ-agonist-induced convulsive activity and antinociception in mice. J.Pharmacol.Exp.Ther. 303 723. PMID: 12388657.

Chang et al (1993) A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86. J.Pharmacol.Exp.Ther. 267 852. PMID: 8246159.

Dykstra et al (1993) A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration. J.Pharmacol.Exp.Ther. 267 875. PMID: 8246162.

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Keywords: BW 373U86, supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, BW373U86, GlaxoSmithKline, GSK, Tocris Bioscience, δ Opioid Receptor Agonist products

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