Jasplakinolide

Cat. No. 2792

Jasplakinolide C36H45BrN4O6 [102396-24-7]

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Chemical Name: Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]

Biological Activity

Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable.

Technical Data

M.Wt:
709.67
Formula:
C36H45BrN4O6
Solubility:
Soluble to 2 mg/ml in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
102396-24-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Bubb et al (2000) Effects of jasplakinolide on the kinetics of actin polymerization. J.Biol.Chem. 275 5163. PMID: 10671562.

Cramer (1999) Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr.Biol. 9 1095. PMID: 10531004.

Bubb et al (1995) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J.Biol.Chem. 269 14869. PMID: 8195116.

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Citations are publications that use Tocris products. Selected citations for Jasplakinolide include:

Krawczyk et al (2015) Myocardin Family Members Drive Formation of Caveolae. PLoS One 10 e0133931. PMID: 26244347.

LeClaire and Fortwendel (2015) Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins. PLoS One 10 e0142535. PMID: 26555617.

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Keywords: Jasplakinolide, supplier, actin, f-actin, monomers, polymerization, polymerisation, stabilizers, stabilizes, inducers, induces, polymers, actin, Tocris Bioscience, Actin products

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