Cat. No. 5151
Biological ActivityPotent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.
(Modifications: Ala-2 = D-Ala)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529. PMID: 23690594.
Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 94 4778. PMID: 9114068.
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Keywords: Prosaptide TX14(A), supplier, Potent, GPR37, GPR37L1, orphan, receptors, agonists, PTX-sensitive, neuroprotective, glioprotective, Tocris Bioscience, Orphan 7-TM Receptor Agonist products
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