Cat. No. 5150
Chemical Name: 3-[(6-Ethynyl-9H-purin-2-yl)amino]b
Biological ActivityPotent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141. PMID: 24213855.
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Keywords: NCL 00017509, supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Tocris Bioscience, Other Kinase Inhibitor products
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