Cat. No. 5149
Chemical Name: 2,3,6a,7,8,9-Hexahydro-11H-1,4-diox
Biological ActivityAMPAkine; positive allosteric modulator of AMPA. Prototypical benzamide which occupies subsite A only. Modulates channel deactivation and desensitization.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Harms et al (2013) Functional analysis of a novel positive allosteric modulator of AMPA receptors derived from a structure-based drug design strategy. Neuropharmacology 64 45. PMID: 22735771.
Timm et al (2011) Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol. 80 267. PMID: 21543522.
Hennegriff et al (1997) Stable expression of recombinant AMPA receptor subunits: binding affinities and effects of allosteric modulators. J.Neurochem. 68 2424. PMID: 9166736 .
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Keywords: CX 614, supplier, CX614, Positive, allosteric, modulators, AMPA, receptors, AMPAkines, benzamide, Tocris Bioscience, AMPA Receptor Modulator products
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November 8 - 10, 2017