AI-3

Cat. No. 5145

AI-3 C11H13ClO3S2 [882288-28-0]

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Chemical Name: 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one

Biological Activity

Antioxidant response element (ARE) activator; disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Induces cytoprotective gene expression in vitro and in vivo.

Technical Data

M.Wt:
292.8
Formula:
C11H13ClO3S2
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
882288-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wang et al (2013) In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem.Biol. 8 1764. PMID: 23773140.

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Keywords: AI-3, supplier, antioxidant, response, element, ARE, NRF2, Nuclear, factor, (erythroid-derived-2)-like, 2, activators, induces, cytoprotective, gene, expression, keap1, Tocris Bioscience, Nrf2 Activator products

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