Cat. No. 5144
Chemical Name: 1-[(2-Chlorophenyl)methyl]-5'-phenyl
Biological ActivityCARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ashour et al (2013) CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS ONE 8 e66733. PMID: 23826121.
Puliyappadamba et al (2011) Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J.Biol.Chem. 286 38000. PMID: 21903591.
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Keywords: CFM 4, supplier, CFM4, CARP-1, mimetic, proapoptotic, antitumor, antitumorgenic, APC-2, G2M, cell, cycle, arrest, Tocris Bioscience, Apoptosis Inducing products