CFM 4

Cat. No. 5144

CFM 4 C22H16ClN3OS [331458-02-7]

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Chemical Name: 1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one

Biological Activity

CARP-1 mimetic; interferes with CARP-1 binding to APC-2. Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses cell growth in cancer cells.

Technical Data

M.Wt:
405.9
Formula:
C22H16ClN3OS
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
331458-02-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ashour et al (2013) CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS ONE 8 e66733. PMID: 23826121.

Puliyappadamba et al (2011) Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis. J.Biol.Chem. 286 38000. PMID: 21903591.

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Keywords: CFM 4, supplier, CFM4, CARP-1, mimetic, proapoptotic, antitumor, antitumorgenic, APC-2, G2M, cell, cycle, arrest, Tocris Bioscience, Apoptosis Inducing products

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