Mps1-IN-1 dihydrochloride

Cat. No. 5142

Mps1-IN-1 dihydrochloride C28H33N5O4S.2HCl

Price and Availability

For Mps1-IN-1 dihydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride

Biological Activity

Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>98 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868. PMID: 21802008.

Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359. PMID: 20383151.

Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21. PMID: 20624898.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Mps1-IN-1 dihydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Mps1-IN-1 dihydrochloride, supplier, Selective, monopolar, spindle, 1, Mps1, kinases, inhibitors, inhibits, mitosis, Tocris Bioscience, Monopolar Spindle 1 Kinase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

PI 3065

Potent and selective PI 3-kinase p110δ inhibitor


Potent and selective PFKFB3 inhibitor

STOCK2S 26016

Lysine deficient protein kinase (WNK) signaling inhibitor

rac-CCT 250863

Potent Nek2 inhibitor


Potent, selective cyclin-dependent kinase inhibitor


Potent PKCβ inhibitor

BMS 265246

Potent cdk1/2 inhibitor

Autocamtide-2-related inhibitory peptide, myristoylated

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide

MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable


Potent and selective dual Akt1 and 2 inhibitor

VX 680

High affinity and selective Aurora kinase inhibitor

Imatinib mesylate

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

TGX 221

Potent and selective PI 3-kinase β inhibitor

PF 543 hydrochloride

Potent and selective SphK1 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.