Mps1-IN-1 dihydrochloride

Cat. No. 5142

Mps1-IN-1 dihydrochloride C28H33N5O4S.2HCl

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Chemical Name: 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride

Biological Activity

Selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

Technical Data

M.Wt:
608.58
Formula:
C28H33N5O4S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868. PMID: 21802008.

Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359. PMID: 20383151.

Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21. PMID: 20624898.

If you know of a relevant reference for Mps1-IN-1 dihydrochloride please let us know.

Citations are publications that use Tocris products.

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Keywords: Mps1-IN-1 dihydrochloride, supplier, Selective, monopolar, spindle, 1, Mps1, kinases, inhibitors, inhibits, mitosis, Tocris Bioscience, Monopolar Spindle 1 Kinase Inhibitor products

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