AZD 5582 dihydrochloride
Cat. No. 5141
Chemical Name: 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[
Biological ActivityDimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.
Licensing InformationSold with the permission of AstraZeneca UK Ltd
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582). J.Med.Chem. 56 9897. PMID: 24320998.
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Keywords: AZD 5582 dihydrochloride, supplier, AZD5582, dihydrochloride, dimeric, smac, inhibitors, potent, x-linked, cellular, cIAP1, cIAP2, XIAP, IAP, inhibits, apoptosis, protein, anticancer, BIR3, domain, 1258392-53-8, Tocris Bioscience, Inhibitor of Apoptosis Inhibitor products
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