Cat. No. 2786
Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N
Biological ActivitySelective calcium chelator.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hardie (2005) Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium 38 547. PMID: 16140375.
If you know of a relevant reference for BAPTA please let us know.
Citations are publications that use Tocris products. Selected citations for BAPTA include:
Birnbaum et al (2015) Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss. PLoS One 6 e1791. PMID: 26086964.
Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545. PMID: 25751534.
Tabatadze et al (2015) Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus. J Neurosci 35 11252. PMID: 26269634.
Vemana et al (2015) A critical role for the transient receptor potential channel type 6 in human platelet activation. Cell Commun Signal 10 e0125764. PMID: 25928636.
Carlsen and Perrier (2014) Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord. Front Neural Circuits 8 60. PMID: 24926236.
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Cell Death Dis 7 62. PMID: 25071439.
Alpert and Alford (2013) Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons. PLoS One 8 e63154. PMID: 23646190.
Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259. PMID: 22347811.
Arozarena et al (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19 45. PMID: 21215707.
Reneau et al (2009) Phorbol 12-myristate 13-acetate potentiation of N-methyl-D-aspartate-induced currents in primary cultured cerebellar granule cells is mediated by protein kinase C alpha. J Pharmacol Exp Ther 330 641. PMID: 19429793.
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Keywords: BAPTA, supplier, Selective, Ca2+, chelator, calcium, Signaling, Signalling, Agents, General, Reagents, Tocris Bioscience, Biochemicals and Molecular Biology products
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