LY 255283

Cat. No. 2208

LY 255283 C19H28N4O3 [117690-79-6]

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Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone

Biological Activity

Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. .

Technical Data

M.Wt:
360.46
Formula:
C19H28N4O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
117690-79-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Yokomizo et al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454. PMID: 11278893.

Herron et al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818. PMID: 1316967.

Silbaugh et al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57. PMID: 1335877.

If you know of a relevant reference for LY 255283 please let us know.

Citations are publications that use Tocris products. Selected citations for LY 255283 include:

Cabral et al (2015) Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PLoS One 3. PMID: 26216432.

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Keywords: LY 255283, supplier, Selective, competitive, BLT2, receptor, antagonists, CysLT1, Receptors, CysLT2, BLT1, OXE, Oxoeicosanoid, receptors, LTD4, LTE4, leukotrienes, eicosanoids, LY255283, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products

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