LY 255283

Cat. No. 2208

LY 255283 C19H28N4O3 [117690-79-6]

Price and Availability

For LY 255283 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]ethanone

Biological Activity

Selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively). Inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration. .

Technical Data

M.Wt:
360.46
Formula:
C19H28N4O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
117690-79-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yokomizo et al (2001) Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J.Biol.Chem. 276 12454. PMID: 11278893.

Herron et al (1992) Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones. J.Med.Chem. 35 1818. PMID: 1316967.

Silbaugh et al (1992) Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. Eur.J.Pharmacol. 223 57. PMID: 1335877.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for LY 255283 include:

Cabral et al (2015) Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis. PLoS One 3. PMID: 26216432.

Do you know of a great paper that uses LY 255283 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: LY 255283, supplier, Selective, competitive, BLT2, receptor, antagonists, CysLT1, Receptors, CysLT2, BLT1, OXE, Oxoeicosanoid, receptors, LTD4, LTE4, leukotrienes, eicosanoids, LY255283, Tocris Bioscience, Leukotriene and Related Receptor Antagonist products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

New Products in this Area

ZQ 16

Selective GPR84 agonist

IHR-Cy3

Potent fluorescent Smo antagonist

Ro 6842262

Potent LPA1 antagonist

AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

AM 4668

Potent FFA1 (GPR40) agonist

CATPB

FFA2 antagonist/inverse agonist

Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

A 971432

Potent and selective S1P5 agonist

GLPG 0974

Potent FFA2 antagonist

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.