Telmisartan

Cat. No. 5139

Telmisartan C33H30N4O2 [144701-48-4]

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Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid

Biological Activity

Antagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.

Technical Data

M.Wt:
514.62
Formula:
C33H30N4O2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
144701-48-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rong et al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096. PMID: 19770292.

Benson et al (2004) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993. PMID: 15007034.

Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040. PMID: 8258826.

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Citations are publications that use Tocris products. Selected citations for Telmisartan include:

Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709. PMID: 26316709.

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Keywords: Telmisartan, supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products

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