Cat. No. 5139
Chemical Name: 4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H
Biological ActivityAntagonist of the angiotensin II type 1 receptor (AT1) (Ki = 3.7 nM). Exhibits antihypertensive activity in a renin-dependent model of hypertension. Partial agonist of PPARγ receptors; shown to improve insulin sensitivity in rodents receiving high fat diets.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Rong et al (2009) An adipose tissue-independent insulin-sensitizing action of telmisartan: a study in lipodystrophic mice. J.Pharmacol.Exp.Ther. 331 1096. PMID: 19770292.
Benson et al (2004) Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPAR γ-modulating activity. Hypertension 43 993. PMID: 15007034.
Ries et al (1993) 6-substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J.Med.Chem. 36 4040. PMID: 8258826.
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Citations are publications that use Tocris products. Selected citations for Telmisartan include:
Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Psychopharmacology (Berl) 9 4709. PMID: 26316709.
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Keywords: Telmisartan, supplier, angiotensin, II, AT1, antagonists, peroxisome, proliferator-activated, receptors, PPARg, PPARgamma, PPARγ, Tocris Bioscience, Angiotensin AT1 Receptor Antagonist products
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April 10 - 13, 2017