Cat. No. 5138
Chemical Name: 2-[[4-(Diethylamino)-2-hydroxypheny
Biological ActivityAMP-activated protein kinase (AMPK) activator (EC50 = 1 μM); activates AMPK indirectly through a CaMKKβ-dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 μM). Induces autophagy and promotes Aβ degradation in vitro. Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Capiralla et al (2012) Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FASEB J. 279 3791. PMID: 22909341.
Vingtdeux et al (2011) Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-ß peptide degradation. FASEB J. 25 219. PMID: 20852062.
Vingtdeux et al (2011) Small-molecule activators of AMP-activated protein kinase (AMPK), RSVA314 and RSVA405, inhibit adipogenesis. Mol Med 17 1022. PMID: 21647536.
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Keywords: RSVA 405, supplier, RSVA405, AMP-activated, protein, kinases, activators, inhibitors, STAT3, indirect, Ab, Abeta, Aβ, amyloid, metabolism, nf-kb, nf-κb, cytokines, inhibits, Tocris Bioscience, AMPK Activator products
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