Cat. No. 5136
Alternative Name: MK 462
Chemical Name: N,N-Dimethyl-5-(1H-1,2,4-triazol-1-
Biological Activity5-HT1B/1D agonist. Antimigraine agent; attenuates effects of CGRP on light aversion in mice. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Kaiser et al (2012) Modulation of CGRP-induced light aversion in wild-type mice by a 5-HT1B/D agonist. J.Neurosci. 32 15439. PMID: 23115181.
Street et al (1995) Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors. J.Med.Chem. 38 1799. PMID: 7752204.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Rizatriptan benzoate from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Rizatriptan benzoate, supplier, selective, 5-HT, serotonin, 5-HT1D, 5-HT1B, receptors, agonists, Rizatriptan, benzoate, serotonergics, MK462, Tocris Bioscience, 5-HT1B Receptor Agonist products