Cat. No. 5133
Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethox
Biological ActivityPotent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Johnson et al (2007) Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells. Biochem.Soc.Trans. 35 1208. PMID: 17956314.
Coope et al (2006) Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 149 328. PMID: 16921397.
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Keywords: GKA 50, supplier, GKA50, glucokinases, hexokinase, IV, HK4, activators, activates, Tocris Bioscience, Hexokinases Activator products
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