GKA 50

Cat. No. 5133

GKA 50 C26H28N2O6 [851884-87-2]

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Chemical Name: 6-[[3-[(1S)-2-Methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino-3-pyridinecarboxylic acid

Biological Activity

Potent glucokinase activator (EC50 = 33 nM). Significantly reduces plasma glucose levels in diabetic rats; stimulates insulin release from mouse islets of Langerhans.

Technical Data

M.Wt:
464.51
Formula:
C26H28N2O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
851884-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Johnson et al (2007) Glucokinase activators: molecular tools for studying the physiology of insulin-secreting cells. Biochem.Soc.Trans. 35 1208. PMID: 17956314.

Coope et al (2006) Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats. Br.J.Pharmacol. 149 328. PMID: 16921397.

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Keywords: GKA 50, supplier, GKA50, glucokinases, hexokinase, IV, HK4, activators, activates, Tocris Bioscience, Hexokinases Activator products

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