Cat. No. 5131

NAB 2 C23H20ClN3O [1504588-00-4]

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Chemical Name: N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide

Biological Activity

Protects against α-synuclein toxicity. Reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. Promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Chung et al (2013) Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 342 983. PMID: 24158904.

Tardiff et al (2013) Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342 979. PMID: 24158909.

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Keywords: NAB 2, supplier, NAB2, α, alpha-synuclein, a-synuclein, toxicity, Parkinsons, disease, parkinson's, NEDD4, rsp5, Tocris Bioscience, Ubiquitin E3 Ligase products

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