Cat. No. 5130
Biological ActivityCXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model.
(Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hassan et al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int.J.Cancer. 129 225. PMID: 20830712.
Kwong et al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893. PMID: 19567818.
Faber et al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065. PMID: 17541466.
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Keywords: CTCE 9908, supplier, CTCE9908, CXCR4, receptor, chemokines, antagonists, ovarian, cancer, mitotic, catastrophe, mitosis, Tocris Bioscience, Chemokine CXC Receptor Antagonist products
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