TC-G 1005

Cat. No. 5129

TC-G 1005 C25H25N3O2 [1415407-60-1]

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Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone

Biological Activity

Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.

Technical Data

M.Wt:
399.48
Formula:
C25H25N3O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1415407-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475. PMID: 23148522.

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Keywords: TC-G 1005, supplier, TC-G1005, TGR5, agonists, agonism, GLP-1, GPBA, glucose, bile, acid, receptors, Tocris Bioscience, GPBA Receptor Agonist products

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