Cat. No. 5129
Chemical Name: (4-Cyclopropyl-3,4-dihydro-1(2H)-qu
Biological ActivityPotent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475. PMID: 23148522.
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Keywords: TC-G 1005, supplier, TC-G1005, TGR5, agonists, agonism, GLP-1, GPBA, glucose, bile, acid, receptors, Tocris Bioscience, GPBA Receptor Agonist products
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