C 21

Cat. No. 5128

C 21 Ac-Ser-Gly-[N5-(2-Chloro-1-iminoethyl)]-Orn-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-Val

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Biological Activity

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.

Technical Data

M.Wt:
2166.94
Formula:
C90H161ClN36O24
Sequence:
SGXGKGGKGLGKGGAKRHRKV

(Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1229236-78-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Obianyo and Thompson (2012) Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J.Biol.Chem. 287 6062. PMID: 22219200.

Obianyo et al (2010) A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem 11 1219. PMID: 20480486.

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Keywords: C 21, supplier, C21, selective, protein, arginine, methyltransferases, inhibitors, inhibits, PRMT1, epigenetics, histone, transferases, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products

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