P1

Cat. No. 5127

P1 C30H37N3O7S [1461648-55-4]

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Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide

Biological Activity

Protein disulfide isomerase (PDI) inhibitor (IC50 = 1.7 μM). Inhibits proliferation of numerous cancer cell lines. Cell permeable.

Technical Data

M.Wt:
583.7
Formula:
C30H37N3O7S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1461648-55-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase ACS Chem.Biol. 8 2577. PMID: 24070012.

Xu et al (2013) Protein disulfide isomerase interacts with tau protein and inhibits its fibrillization. PLoS One 8 e76657. PMID: 24098548.

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Citations are publications that use Tocris products.

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Keywords: P1, supplier, Protein, disulfide, Isomerase, PDI, inhibitors, inhibits, Tocris Bioscience, Protein Disulphide Isomerase Inhibitor products

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