PD 404182

Cat. No. 5124

PD 404182 C11H11N3S [72596-74-8]

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Chemical Name: 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine

Biological Activity

High affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.

Technical Data

Soluble to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chamoun-Emanuelli et al (2014) Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob.Agents Chemother. 58 687. PMID: 24217696.

Ghebremariam et al (2013) A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide. J.Pharmacol.Exp.Ther. 348 69. PMID: 24135074.

Birck et al (2000) Identification of a slow tight-binding inhibitor of 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase. J.Am.Chem.Soc. 122 9334.

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Citations are publications that use Tocris products.

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Keywords: PD 404182, supplier, PD404182, antibiotics, KDO8-P, antivirals, antiangiogenics, angiogenesis, gram, negative, DDAH1, 3-deoxy-D-manno-octulosonic, acid, 8-phosphate, synthase, dimethylarginine, dimethylaminohydrolase, 1, inhibits, inhibitors, Tocris Bioscience, Other Synthase/Synthetase Inhibitor products

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