Cat. No. 5121
Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-p
Biological ActivityPFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor; reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Schoors et al (2014) Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19 37. PMID: 24332967.
Clem et al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 7 110. PMID: 18202014.
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Keywords: 3PO, supplier, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, antitumor, antitumour, antiangiogenic, Tocris Bioscience, PFKFB3 Inhibitor products
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