Cat. No. 5121
Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-p
Biological ActivityPFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor; reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Schoors et al (2014) Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 19 37. PMID: 24332967.
Clem et al (2008) Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol.Cancer Ther. 7 110. PMID: 18202014.
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Keywords: 3PO, supplier, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, antitumor, antitumour, antiangiogenic, Tocris Bioscience, PFKFB3 Inhibitor products
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