Cat. No. 5116
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-
Biological ActivityIrreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577. PMID: 24070012.
Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348. PMID: 22988091.
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Keywords: PACMA 31, supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Tocris Bioscience, Protein Disulphide Isomerase Inhibitor products
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