Cat. No. 5116
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-
Biological ActivityIrreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577. PMID: 24070012.
Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348. PMID: 22988091.
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Keywords: PACMA 31, supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Tocris Bioscience, Other Reductase Inhibitor products