Cat. No. 5116
Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-
Biological ActivityIrreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577. PMID: 24070012.
Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348. PMID: 22988091.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PACMA 31 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PACMA 31, supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Tocris Bioscience, Other Reductase Inhibitor products