PACMA 31

Cat. No. 5116

PACMA 31 C21H22N2O6S [1401089-31-3]

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Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester

Biological Activity

Irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

Technical Data

M.Wt:
430.47
Formula:
C21H22N2O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
1401089-31-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577. PMID: 24070012.

Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348. PMID: 22988091.

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Keywords: PACMA 31, supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Tocris Bioscience, Protein Disulphide Isomerase Inhibitor products

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