Cat. No. 2004
Alternative Name: PN 200-110
Chemical Name: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-di
Biological ActivityPotent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ruegg and Hof (1990) Pharmacology of the calcium antagonist isradipine. Drugs 40 3.
Wada et al (1985) Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 7 190. PMID: 2580142.
Hof et al (1984) PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 6 399. PMID: 6202964.
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Citations are publications that use Tocris products. Selected citations for Isradipine include:
Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neurosci 10 e0117555. PMID: 25689857.
Dragicevic et al (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. PLoS One 137 2287. PMID: 24934288.
Saszik and DeVries (2012) A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light. J Neurosci 32 297. PMID: 22219291.
Do you know of a great paper that uses Isradipine from Tocris? If so please let us know.
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Keywords: Isradipine, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, PN200110, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products
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