RWJ 21757

Cat. No. 2719

RWJ 21757 C13H17N5O6 [121288-39-9]

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Alternative Names: Loxoribine, 7-Allyl-8-oxoguanosine

Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine

Biological Activity

Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.

Technical Data

Soluble to 20 mM in water and to 75 mM in DMSO
>97 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987. PMID: 14579267.

Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646. PMID: 12738885.

Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457. PMID: 7949100.

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Keywords: RWJ 21757, supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Tocris Bioscience, Toll-like Receptor Agonist products

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