Cat. No. 2719
Alternative Names: Loxoribine, 7-Allyl-8-oxoguanosine
Chemical Name: 7,8-Dihydro-8-oxo-7-(2-propenyl)gua
Biological ActivityToll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Heil et al (2003) The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J.Immunol. 33 2987. PMID: 14579267.
Lee et al (2003) Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7. Proc.Natl.Acad.Sci.USA 100 6646. PMID: 12738885.
Goodman et al (1994) Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Blood 84 3457. PMID: 7949100.
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Keywords: RWJ 21757, supplier, Toll-like, receptors, 7, TLR7, agonists, RWJ21757, Tocris Bioscience, Toll-like Receptor Agonist products
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