PLX 647 dihydrochloride

Cat. No. 5102

PLX 647 dihydrochloride C21H17F3N4.2HCl

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Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride

Biological Activity

Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Technical Data

M.Wt:
455.3
Formula:
C21H17F3N4.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689. PMID: 23493555.

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Keywords: PLX 647 dihydrochloride, supplier, PLX647, dihydrochloride, potent, selective, FMS, KIT, dual, inhibitors, kinases, proliferation, antiproliferative, differentiation, osteoclasts, inhibits, Tocris Bioscience, Other RTKs Inhibitor products

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