Cat. No. 5101
Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-meth
Biological ActivityA nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266. PMID: 23103525.
Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63. PMID: 18289033.
Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505. PMID: 15051797.
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Keywords: PD 90780, supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, NGF, receptor, TrkA, neuroprotective, nerve, growth, factors, Tocris Bioscience, Trk Receptor products
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