PD 90780

Cat. No. 5101

PD 90780 C19H14N4O4 [77422-99-2]

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Chemical Name: 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid

Biological Activity

A nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells); binds NGF, not p75NTR. Affinity maybe altered by the presence of TrkA receptors. Neuroprotective.

Technical Data

M.Wt:
362.34
Formula:
C19H14N4O4
Solubility:
Soluble to 20 mM in 1eq. NaOH with sonication
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
77422-99-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Eibl et al (2012) Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor. Neurochem.Int. 61 1266. PMID: 23103525.

Longo et al (2008) Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol.Disord.Drug Targets 7 63. PMID: 18289033.

Colquhoun et al (2004) Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J.Pharmacol.Exp.Ther. 310 505. PMID: 15051797.

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Citations are publications that use Tocris products.

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Keywords: PD 90780, supplier, PD90780, nonpeptide, inhibitors, inhibits, of, NGF, binding, p75, NGF, receptor, TrkA, neuroprotective, nerve, growth, factors, Tocris Bioscience, Trk Receptor products

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