TC-T 6000

Cat. No. 5100

TC-T 6000 C26H48N8O2 [949467-71-4]

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Chemical Name: 2,2'-[[4,8-Bis[bis(2-methylpropyl)amino]pyrimido[5,4-d]pyrimidine-2,6-diyl]diimino]bis-ethanol

Biological Activity

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor (IC50 = 74.4 nM). Exhibits 20-fold and 80-fold selectivity for ENT4 over ENT2 and ENT1, respectively.

Technical Data

M.Wt:
504.71
Formula:
C26H48N8O2
Solubility:
Soluble to 20 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
949467-71-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wang et al (2013) Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochem.Pharmacol. 86 1531. PMID: 24021350.

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Keywords: TC-T 6000, supplier, potent, selective, ENT4, inhibitors, inhibits, equilibrative, nucleoside, transporter, 4, Tocris Bioscience, Nucleoside Transporter Inhibitor products

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