TC-E 5003

Cat. No. 5099

TC-E 5003 C16H14Cl2N2O4S [17328-16-4]

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Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide)

Biological Activity

Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.

Technical Data

M.Wt:
401.26
Formula:
C16H14Cl2N2O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
17328-16-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717. PMID: 21440447.

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Keywords: TC-E 5003, supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products

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