Cat. No. 5099
Chemical Name: N,N'-(Sulfonyldi-4,1-phenylene)bis(2
Biological ActivitySelective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM); exhibits no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Attenuates androgen-induced gene expression in LNCaP cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Bissinger et al (2011) Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg.Med.Chem. 19 3717. PMID: 21440447.
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Keywords: TC-E 5003, supplier, TC-E5003, selective, PRMT1, inhibitors, inhibits, protein, methyltransferases, arginine, epigenetics, histone, transferases, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products
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